Phone: 724-503-1001 x5285
Office: Dieter-Porter 008
Email: klohr@ngskmc-eis.net
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Neuroscience, Molecular Biology
Kelly Lohr, Ph.D.
Assistant Professor of Biology
Academic Program: Biomedical Science, Cell and Molecular Biology, Conservation Biology, Biology
Degrees: Ph.D. Neuroscience, Emory University; B.S. Neuroscience, Dickinson College
Kelly M. 洛尔是生物系的助理教授. 她教授分子生物学、基因组学和神经科学课程.
Dr. 洛尔在迪金森学院学习神经科学. She earned her Ph.D. 来自亚特兰大埃默里大学的神经科学专业, 在那里，她研究了帕金森病中神经递质多巴胺的储存和释放的变化. Prior to joining the faculty at W&J, Dr. 洛尔是波士顿布里格姆妇女医院和哈佛医学院的博士后研究员, 马萨诸塞州研究果蝇神经退行性疾病的遗传因素, Drosophila melanogaster. 她在《det365手机版官网》和《det365手机版官网》等期刊上发表了多篇科学论文，并在国家会议上发表了她的研究成果. 她的研究兴趣是基因与环境的相互作用以及对阿尔茨海默病和帕金森病等神经退行性疾病毒性的次要贡献.
Publications
- 张勇，刘建军，刘建军，刘建军，刘建军， & Feany MB. (2021) Lrrk寡聚化控制肌动蛋白 切断和α-突触核蛋白的体内神经毒性. Molec Neurodegen, 16(33). Link to entry
- Sarkar S, Olsen AL, Sygnecka K, Lohr KM， & Feany MB. (2021) α-synuclein通过异常的肌动蛋白稳定损害自噬体成熟. PLOS Genetics, 17(2). Link to entry
- Lohr KM, Frost B, Scherzer C, & Feany MB. (2020). 生物素在牛头病模型中拯救线粒体功能障碍和神经毒性. Proc Natl Acad Sci,117(52):33608-33618. Link to entry
- Branco RC, Burkett J, Black CA, Winokur, E, Elsworth W, Dhamasania, R, Lohr, KM, Schroeder, JP, Weinshenker, D, Jovanovic, T, Miller GW. (2020)水疱单胺转运蛋白2介导小鼠的恐惧行为. Genes Brain Behav, e12634/ Link to entry
- Lohr KM, Masoud S, Salahpour A, & Miller GW. (2017). 膜转运体作为突触多巴胺动力学的介质:对疾病的影响. Europ J Neurosci, 45(1): 2-33. Link to entry
- Dunn AR, Stout KA, Ozawa M, Lohr KM, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM, & Miller GW. (2017)突触囊泡糖蛋白2C (SV2C)调节多巴胺释放 disrupted in Parkinson's disease. Proc Natl Acad Sci, 114(11):2253-2262. Link to entry
- Lohr KM, Chen M, Hoffman C, McDaniel M, Stout KA, Dunn AR, Bernstein AI, Wang M， & Miller GW. (2016). 水疱单胺转运蛋白2 (VMAT2)水平调节小鼠纹状体终末MPTP易感性和过量多巴胺的清除. Toxicol Sci, 153(1):79-88. Link to entry
- Cliburn RC, Dunn AR, Stout KA, Hoffman CA, Lohr KM, Bernstein AI, Winokur EJ, Burkett J, Shmitz Y， & Miller GW. (2016)小鼠脑内单胺转运蛋白2的免疫化学定位. J Chem Neuroanat, 0618(16)30095-3. Link to entry
- Stout KA, Dunn AR, Lohr KM, Ozawa M, Alter SP, Cliburn RC, Guillot TS， & Miller GW. (2016) Selective 甲基苯丙胺致敏小鼠腹侧苍白球多巴胺释放增强. ACS Chem Neurosci, 7(10):1364-1373. Link to entry
- Trossbach SV, Bader V, Hecher L, Pum ME, Schäble S, Prikulis I, de Souza Silva MA, Godsave SF, Peters PJ, Steiner H, Weisshaupt A, Bilzer T, Sauvage M, Boulat B, Chwiesko C, Su P, Liu F, Masoud S, Lohr KM, Stout KA, Miller GW, Bauer A, Ramsey AJ, Brandon NJ, Seeman P, Huston JP, & Korth C. (2016)全长精神分裂症1 (DISC1)蛋白的错误组装与多巴胺稳态改变和行为缺陷有关. Mol Psych, 21(11):1561-1572. Link to entry
- Lohr KM, Stout KA, Dunn AR, Wang M, Salahpour A, Guillot TS， & Miller GW. (2015). Increased vesicular monoamine transporter 2 (VMAT2; Slc18a2) protects against methamphetamine toxicity. ACS Chem Neuroscience, 6(5): 790-799. Link to entry
- Alter SP, Stout KA, Lohr KM, Taylor TN, Shepherd KR, Wang M, Guillot TS, Miller GW. (2015). 减少水泡单胺运输破坏血清素信号，但不引起血清素能变性. Exp Neurol, 1:17-24. Link to entry
- Coughlan C, Walker DI, Lohr KM, Lazo CR, Richardson JR, Saba LM, Caudle WM, Fritz KS， & Roede, JR. (2015). 农药处理小鼠纹状体和皮层羰基化蛋白的比较蛋白质组学分析. Parkinson’s Disease, Art. ID: 812532. Link to entry
- Liu G, Sgobio C, Gu X, Sun L, Lin X, Yu J, Parisiadou L, Xie C, Sastry N, Ding J, Lohr KM, Miller GW, Mateo Y, Lovinger DM, & Cai H. (2015)帕金森病相关的富亮氨酸重复激酶2 G2019S错义突变在中脑多巴胺能神经元中的选择性表达损害多巴胺释放和多巴胺能基因表达. Hum Mol Genet, 24(18):5299-312. Link to entry
- Lohr KM & Miller GW. (2014) VMAT2与帕金森病:利用多巴胺囊泡. Expert Rev Neurother, 14:1-3. Link to entry
- Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP，等. (2014)在体内，单胺转运蛋白表达增加可促进多巴胺释放，对抗帕金森病相关神经退行性变. Proc Natl Acad Sci, 111 (27) 9977-9982. Link to entry
- Niblock MM, Lohr KM, Nixon M, Barnes C, Schaudies M， & Murphy M. (2011). 雌性后梯形区的细胞上调c-fos，上调幅度为10%, but not 5%, carbon dioxide. Brain Research, 1433: 62-68. Link to entry
